謝建台 教授 (Prof. Shiea Jentaie)

刑事鑑識一直以來都扮演著輔助案件偵查的重要角色，隨著時代的進步，越來越講究科學辦案，但傳統分析往往受限於時間與成本，導致分析的結果
動輒花上數天。本實驗開發各種大氣質譜法結合各式質譜儀，可直接對物品、不明液體、甚至皮膚上直接進行分析，具有快速、即時、高通量等優點，
為阻嚇犯罪的一大利器。

代表性著作

1. Cho, Y. T.; Su, H.; Huang, T. L.; Chen, H. C.; Wu, W. J.; Wu, P. C.; Wu, D. C. ; Shiea, J., “Matrix-assisted Laser Desorption Ionization/time-of-flight Mass Spectrometry for Clinical Diagnosis” Clin. Chim. Acta 2013, 415, 266-275. (Invited Review Article, Citation: 42)
2. Cheng, S.C.; Huang,  M. Z.; Shiea, J., “Thin Layer Chromatography/Mass Spectrometry”  J. Chromatogr. A, 2011, 1218, 2700-2711. (Invited Review Article, Citation: 104)
3. Huang, M. Z.; Cho, Y. T.; Cheng, S. C.; Shiea, J., “Ambient Ionization Mass Spectrometry - A Tutorial” Anal. Chim. Acta 2011, 702, 1-15. (Invited Review Article, Citation: 257)
4. Huang, M. Z.; Yuan, C. H.; Cheng, S. C.; Cho, Y. T.; Shiea, J., “Ambient Ionization Mass Spectrometry” Annual Review Analytical Chemistry, 2010, 3, 43-65. (Citation: 252)
5. Shiea, J.; Huang, M. Z.; Hsu, H. J.; Lee, C. Y.; Yuan, C. H.; Beech, I.; Sunner, J., Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids. Rapid Commun. Mass Spectrom. 2005, 19(24), 3701-3704. (Citation: 478)
6. Chang, D. Y.; Lee, C. C.; Shiea, J., Detecting Large Biomolecules from High-salt Solutions by Fused-droplet Electrospray Ionization Mass Spectrometry. Anal. Chem. 2002, 74(11), 2465-2469. (Citation: 131)
7. Yuan, C. H.; Shiea, J., Sequential Electrospray Analysis Using Sharp-tip Channels Fabricated on a Plastic Chip. Anal. Chem. 2001, 73(6), 1080-1083. (Citation: 142)

專書/專刊

1. Shiea, J.; Shimma S.; Lai, C. C., A Special Issue for 2018 Mass Spectrometry for Clinical Diagnosis. Rapid Commun. Mass Spectrom. 2020, doi: 10.1002/rcm.8702.
2. Su, H.; Lin, J. Y.; Shiea, J., “In-situ Detection of Chemical Compounds Using Ambient Ionization Mass Spectrometry”. 2019, 57, 42-51.
3. Shiea, J., A Special Issue for 2017 Mass Spectrometry for Clinical Diagnosis. J. Food Drug Anal. (Taiwan). 2019, 27, 375-614.
4. Cheng, S.; Shiea, J., “Rapid Characterization of toxic compounds with Ambient Mass Spectrometric system”. SciTech Reports., 2018.
5. Liao, P. C; Shiea, J., A Special Issue for The 13th Annual Conference of the Taiwan Society for Mass Spectrometry. Mass Spectrom. (Tokyo) . 2017, 6(2): K0010.
6. Cheng, S.; Su, H.; Lee, R. H.; Cai, Y. D.; Lee, C. W.; Shiea, J., “Rapid Characterization of Pesticides and Drugs in Biofluids and on  Solid Samples with Thermal Desorption Electrospray Ionization Mass Spectrometry”. Taiwan I. Forensic Medicine, 2016, 8(2), 28-41.
7. Cheng, S.; Shiea, J., “Interfacing TLC with Laser-Based Ambient Mass Spectrometry”. Planar. Chromatogr. Mass Spectrom., 2015, 110, 105-118.
8. Su, H.; Shiea, J., “Laser-Based Molecular Imaging Mass Spectrometry ”. Instrum. Today, 2015, 203, 7-16.
9. Huang, M. Z.; Jhang, S. S.; Shiea, J., “Electrospray Laser Desorption Ionization (ELDI) Mass Spectrometry for Molecular Imaging of Small Molecules on Tissues”. Mass Spectrom. Imaging of Small Molecules, 2015, 1203, 107-116.
10. Cho, Y. T.; Su, H.; Wu, W. J.; Wu, D. C.; Hou, M. F.; Kuo, C. H.; Shiea, J., “Biomarker Characterization by MALDI-TOF/MS”. Adv. Clin. Chem. 2015, 69, 209-254.
11. Huang, M. Z.; Jhang, S. S.; Chan, Y. T.; Cheng, S. C.; Cheng, C. N.; Shiea, J., “Electrospray Laser Desorption Ionization Mass Spectrometry”. Ambient Ionization Mass Spectrom., 2014, 372-388.
12. Cheng, S.; Shiea, J., “Advanced Spectroscopic Detectors for Identification and Quantification: Mass Spectrometry”. Instrum. Thin-Layer Chromatogr., 2014, 249-278.
13. Li, L. J.; Liao, P. C.; Shiea, J., Mass Spectrometry for Clinical Diagnosis Preface. Clin. Chim. Acta 2013, 420, 1-3.
14. Shiea, J.; Chou, C. C.; “Mobile Ambient Mass Spectroscopy” Instrum. Today, 2012, 187, 3-9.
15. Cheng, C. N.; Lai, J. H.; Huang, M. Z.; Oung, J. N.; Shiea, J.; “Analysis of Polar Components in Crude Oil by Ambient Mass Spectrometry" in "Crude Oil Emulsions – Composition Stability and Characterization" (ed. M. El-Sayed Abdul-Raouf). Intech, 2012, 6, 107-120.

期刊論文(1995-2020)

2020

• Chan, H. C.; Chan, H. C.; Liang, H. J.; Lee, H. C.; Su, H.; Lee, A. S.; Shiea, J.; Tsai, W. C.; Ou, T. T.; Wu, C. C.; Chu, C. S.; Dixon, R. A.; Ke, L. Y.; Yen, J. H.; Chen, C. H., Role of Low-density Lipoprotein in Early Vascular Aging Associated With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2020, doi: 10.1002/art.41213
• Wang, C. H.; Su, H.; Chou, J. H.; Lin, J. Y.; Huang, M. Z.; Lee, C. W.; Shiea, J., Multiple Solid Phase Microextraction Combined with Ambient Mass Spectrometry for Rapid and Sensitive Detection of Trace Chemical Compounds in Aqueous Solution. Anal. Chim. Acta 2020, 1107, 101-106.
• Su, H.; Huang, Y. J.; Huang, M. Z.; Lee, Y. T.; Chen, S. C.; Hung, C. H.; Kuo, C. H.; Wu, M. T.; Shiea, J., Using Ambient Mass Spectrometry to Explore the Origins of Phthalate Contamination in a Mass Spectrometry Laboratory. Anal. Chim. Acta 2020, 1105, 128-138.
• Cheng, S. C.; Lee, R. H.; Jeng, J. Y.; Lee, C. W.; Shiea, J., Fast screening of trace multiresidue pesticides on fruit and vegetable surfaces using ambient ionization tandem mass spectrometry. Anal. Chim. Acta 2020, 1102, 63-71.

2019

• Shiea, J.; Bhat, S. M.; Su, H.; Ponnusamy, V. K.; Lee, C. W.; Wang, C. H., Rapid Quantification of Acetaminophen in Plasma Using Solid Phase Microextraction Coupled with Thermal Desorption-Electrospray Ionization/Mass Spectrometry. Rapid Commun. Mass Spectrom. 2019, doi: 10.1002/rcm.8564. (Special issue)
• Su, H.; Yeh, I. J.; Wu, Y. H.; J, Z. H.; Shiea, J.; Lee, C. W., Rapid identification of organophosphorus pesticides on contaminated skin and confirmation of adequate decontamination by ambient mass spectrometry in emergency settings. Rapid Commun. Mass Spectrom. 2019, doi: 10.1002/rcm.8562. (Special issue)
• Su, H.; Lin Y. P.; Yang, S. C.; Kuo, C. H.; Wu, D. C.; Shiea, J.; Lee, C. W., Rapid detection of non-volatile household pesticides in drained gastric juice by ambient mass spectrometry for emergency management. Anal. Chim. Acta 2019, 1066, 69-78.
• Su, H.; Liu, K. T.; Chen, B. H.; Lin, Y. P.; Jiang, Y. M.; Tsai, Y. H.; Chang, F. R.; Shiea, J.; Lee, C. W., Rapid Identification of Herbal Toxins Using Electrospray Laser Desorption Ionization Mass Spectrometry for Emergency Care. J. Food Drug Anal. 2019, 27, 415-427. (Cover image of special issue)
• Cheng, S. C.; Tsai, Y. D.; Lee, C. W.; Chen, B. H.; Shiea, J., Direct and Rapid Characterization of Illicit Drugs in Adulterated Samples Using Thermal Desorption Electrospray Ionization Mass Spectrometry. J. Food Drug Anal. 2019, 27, 451-459. (Special issue)
• Cheng, S. C.; Bhat, S. M.; Lee, C. W.; Shiea, J., Simple Interface for Scanning Chemical Compounds on Developed Thin Layer Chromatography Plates Using Electrospray Ionization Mass Spectrometry. Anal. Chim. Acta 2019, 1049, 1-9.
• Sambandan, E.; Kathavarayan, T.; Sellappan, S.; Shiea, J.; Ponnusamy, V. K., Identification and characterization of unknown degradation impurities in beclomethasone dipropionate cream formulation using HPLC, ESI-MS and NMR. J. Pharm. Biomed. Anal. 2019, 167, 123-131.

2018

• Lee, C. W.; Chao, Y. Y.; Shiea, J., Shen J. H., Lee, H. H.; Chen, B. H., Ambient Mass Spectrometry for Rapid Diagnosis of Psychoactive Drugs Overdose in an Unstable Patient. Am. J. Emerg. Med. 2018, 36(3), 530.e1-530.e5.
• Wu, C. Y.; Lo, L. H.; Su, H.; Shiea, J., Detection of α-defensin in Blister Fluids as Potential Biomarkers for Bullous Pemphigoid Patients by Matrix-assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry. Clin. Chim. Acta 2018, 479, 212-218.
• Wang, C. H.; Su, H.; Chou, J. H.; Huang, M. Z.; Lin, H. J.; Shiea, J., Solid Phase Microextraction Combined with Thermal-desorption Electrospray Ionization Mass Spectrometry for High-throughput Pharmacokinetics Assays. Anal. Chim. Acta 2018, 60-68.
• Lee, C. W.; Su, H.; Lee, R. H.; Lin, Y. P.; Tsai, Y. D.; Wu, D. C.; Shiea, J., Point-of-care Identification of Organophosphates in Gastric Juice by Ambient Mass Spectrometry in Emergency Settings. Clin. Chim. Acta 2018, 288-297.
• Cheng, S. C.; Bhat, S. M.; Lee, C. W.; Shiea, J., Thin Layer Chromatography Combined with Electrospray Ionization Mass Spectrometry for Characterizing Herbal Compounds. Int. J. Mass Spectrom. 2018, 434, 264-271.
  
• Su, H.; Huang, M. Z.; Chou, J. H.; Chang, T. H.; Jiang, Y. M.; Cho, Y. T.; Cheng, S. C.; Wu, M. T.; Shiea J., High-throughput Screening of Phthalate-containing Objects in the Kindergartens by Ambient Mass Spectrometry. Anal. Chim. Acta 2018, 1039, 65-73.

2017

• Lee, C. W.; Su, H.; Cai, Y. D.; Wu, M. T.; Wu, D. C.; Shiea, J., Rapid Identification of Psychoactive Drugs in Drained Gastric Lavage Fluid and Whole Blood Specimens of Drug Overdose Patients Using Ambient Mass Spectrometry. Mass Spectrom. 2017, 6, S0056.
• Cheng, S. C.; Chen, S. H.; Shiea, J., Desorption Flame-Induced Atmospheric Pressure Chemical Ionization Mass Spectrometry for Rapid Real-World Sample Analysis. Mass Spectrom. 2017, 6, S0065.
• Cheng, S. C.; Shiea, C.; Huang, Y. L.; Wang, C. H.; Cho, Y. T.; Shiea, J., Laser-based Ambient Mass Spectrometry. Anal. Methods 2017, 9, 4924-4935.
• Lin, P. D.; Wu, C. F.; Kou, H. S.; Huang, T. Y.; Shiea, J.; Wu, M. T., Removal of Diethylhexyl Phthalate from Hands by Handwashing: Evidence from Experimental N-of-1 and Crossover Designs. Sci. Rep. 2017, 7(1), 454.
• Shiea, C.; Huang, Y. L.; Cheng, S. C.; Chen, Y. L.; Shiea, J., Determination of Elemental Composition of Metals Using Ambient Organic Mass Spectrometry. Anal. Chim. Acta 2017, 968, 50-57.
• Satarpai, T.; Siripinyanond, A.; Su, H.; Shiea, J., Rapid Characterization of Trace Aflatoxin B1 on Groundnuts, wheat and maize by Dispersive Liquid-Liquid Microextraction Followed by Direct Electrospray Probe Tandem Mass Spectrometry. Rapid Commun. Mass Spectrom. 2017, 31, 1-9.
• Cheng, S. C.; Bhat, S. M.; Shiea, J., Flame Atmospheric Pressure Chemical Ionization Coupled with Negative Electrospray Ionization Mass Spectrometry for Ion Molecule Reactions. J. Am. Soc. Mass Spectrom. 2017, 28(7), 1473-1481.
• Cho, Y. T.; Su, H.; Chiang, Y. Y.; Hou, M. F.; Shiea, J.; Yuan, S. F.; Hung, W. C.; Yeh, Y. T., Fine Needle Aspiration Combined with Matrix-Assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry to Rapidly Assist Diagnosing Breast Cancer. Clin. Breast Cancer 2017, 17(5), 373-381.
• Huang, T. L.; Lo, L. H.; Shiea, J.; Su, H., Rapid and Simple Analysis of Disease-associated Biomarkers of Taiwanese Patients with Schizophrenia Using Matrix-assisted Laser Desorption Ionization Mass Spectrometry. Clin. Chim. Acta 2017, 473, 75–81.
• Chang, F. K.; Shiea, J.; Tsai, H. J., Urinary Concentrations of Triclosan, Benzophenone-3, and Bisphenol A in Taiwanese Children and Adolescents. Int. J. Environ. Res. Public Health 2017, 14(12), p: E1545.

2016

• Kao, Y. Y.; Cheng, S. C.; Cheng, C. N.; Shiea, J., Depth Profiling of Inks in Authentic and Counterfeit Banknotes by Electrospray Laser Desorption Ionization/Mass Spectrometry. J. Mass Spectrom. 2016, 51(1) , 20-7.
• Kostyukevich, Y.; Kononikhin, A.; Popov, I.; Kukaev, E.; Shiea, J.; Nikolaev, E., Supermetallization of Peptides and Proteins with Tetravalent Metal Th(IV), Eur. J. Mass Spectrom. 2016, 22(1) , 39-42.
• Kuo, H. K.; Chen, Y. H.; Huang, F.; Wu, Y. C.; Shiea, J.; Wu, P. C., the Upregulation of Zinc Finger Protein 670 and Prostaglandin D2 Synthase in Proliferative Vitreoretinopathy. Graefes. Arch. Clin. Exp. Ophthalmol. 2016, 254(2) , 205-213.
• Lee, C. W.; Su, H.; Chen, P. Y.; Lin, S. J. ; Shiea, J.; Shin, S. J.; Chen, B. H., Rapid Identification of Pesticides in Human Saliva for Emergency Management by Thermal Desorption Electrospray Ionization/Mass Spectrometry. J. Mass Spectrom 2016, 51, 97-104. (Featured article)
• Cheng, S. C.; Chen, Y. T.; Jhang, S. S.; Shiea, J., Flame-induced Atmospheric Pressure Chemical Ionization Mass Spectrometry. Rapid Commun. Mass Spectrom. 2016, 30(7), 890-6.
• Cheng, S. C.; Wang, C. H.; Shiea, J., Formation of Metal-Adducted Analyte Ions by Flame-Induced Atmospheric Pressure Chemical Ionization Mass Spectrometry. Anal. Chem. 2016, 88(10), 5159-65.
• Lee, C. W.; Su, H.; Wu, K. D.; Shiea, J., Wu, D. C.; Shin, S. J.; Chen, B. H. Rapid Point-of-care Identification of Mis-swallowed Oral Medications in Gastric Lavage Content by Ambient Mass Spectrometry in Emergency Room. Rapid Commun. Mass Spectrom. 2016, 30(11), 1295-1303.
• Lo, L. H.; Shiea, J.; Huang, T. L., Rapid Detection of Alteration of Serum IgG in Patients with Schizophrenia after Risperidone Treatment by Matrix-assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry. Rapid Commun. Mass Spectrom. 2016, 30(24), 2645-2649.

2015

• Shiea, C.; Huang, Y. L.; Liu, D. L.; Chou, C. C.; Chou, J. H.; Chen, P. Y.; Shiea, J.; Huang, M. Z., Rapid Screening of Residual Pesticides on Fruits and Vegetables Using Thermal Desorption Electrospray Ionization Mass Spectrometry. Rapid Commun. Mass Spectrom. 2015, 29, 163–170.
• Cheng, S. C.; Chang, S. S.; Huang, M. Z.; Shiea, J., Simultaneously Detecting Polar and Nonpolar Compounds by Ambient ESI/APCI Mass Spectrometry, Anal. Chem. 2015, 87, 1743-1748.
• Kuo, F. C.; Su, S. W.; Wu, C. F.; Huang, M. C.; Shiea, J.; Chen, B. H.; Chen, Y. L.; Wu, M. T., Relationship of Urinary Phthalate Metabolites with Serum Thyroid Hormones in Pregnant Women and Their Newborns: a Prospective Birth Cohort in Taiwan. PLoS One 2015, 10(6), e0123884.

2014

• Cho, Y. T.; Huang, M. Z.; Wu, S. Y.; Hou, M. F.; Li, J. J.; Shiea, J., Using Electrospray Laser Desorption Ionization Mass Spectrometry to Rapidly Examine the Integrity of Proteins Stored in Various Solutions. Anal. Bioanal. Chem. 2014, 406(2), 577-586.
• Kao, Y. Y.; Cheng, S. C.; Cheng, C. N.; Shiea, J.; Ho, H. O., Detection of Trace Ink Compounds in Erased Handwritings Using Electrospray-assisted Laser Desorption Ionization Mass Spectrometry. J. Mass Spectrom. 2014, 49(6), 445-51.
• Wu, C. F.; Liu, C. C.; Chou, Y. H.; Shiea, J.; Shen, J. T.; Wang, S. S.; Wu, M. T., Increased Detection Rate of Melamine-containing Calcium Urolithiasis by Using Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometry Technique in Clinical Practice (vol 431C, pg294, 2014). Clin. Chim. Acta 2014, 435, 62-63.
• Hsu, F. J.; Liu, T. L.; Laskar, A. H.; Shiea, J.; Huang, M. Z., Gravitational Sampling Electrospray Ionization Mass Spectrometry for Real‐time Reaction Monitoring. Rapid Commun. Mass Spectrom. 2014, 28(18), 1979-1986.

2013

• Wu, M. T.; Wu, C. F.; Chen, B. H.; Chen, E. K.; Chen, Y. L.; Shiea, J.; Lee, W. T.; Chao, M. C.; Wu, J. R., Intake of Phthalate-tainted Foods Alters Thyroid Functions in Taiwanese Children. PloS one 2013, 8(1), e55005.
• Cho, Y. T.; Su, H.; Huang, T. L.; Chen, H. C.; Wu, W. J.; Wu, P. C.; Wu, D. C.; Shiea, J., Matrix-assisted Laser Desorption Ionization/Time-of-flight Mass Spectrometry for Clinical Diagnosis. Clin. Chim. Acta 2013, 415, 266-275.
• Kononikhin, A.; Huang, M. Z.; Popov, I.; Kostyukevich, Y.; Kukaev, E.; Boldyrev, A.; Spasskiy, A.; Leypunskiy, I.; Shiea, J.; Nikolaev, E., Signal Enhancement in Electrospray Laser Desorption/Ionization Mass Spectrometry by Using a Black Oxide-coated Metal Target and a Relatively Low Laser Fluence. Eur. J. Mass Spectrom. 2013, 19(4), 247-252.
• Chiu, K. H.; Hsieh, F. M.; Chen, Y. Y.; Huang, H. W.; Shiea, J.; Mok, H. K., Parvalbumin Characteristics in the Sonic Muscle of a Freshwater Ornamental Grunting Toadfish (Allenbatrachus grunniens). Fish Physiol. Biochem. 2013, 39(2), 107-119.
• Cho, Y. T.; Hu, J. L.; Shiea, J.; Chen, C. W.; Su, H.; Chen, H. C.; Wu, W. J.; Wu, D. C., Diagnosis of Albuminuria by Tryptic Digestion and Matrix-assisted Laser Desorption Ionization/Time-of-flight Mass Spectrometry.Clin. Chim. Acta 2013, 420, 76-81.
• Lin, Y. T.; Tsai, M. T.; Chen, Y. L.; Cheng, C. M.; Hung, C. C.; Wu, C. F.; Liu, C. C.; Hsieh, T. J.; Shiea, J.; Chen, B. H.; Wu, M. T., Can Melamine Levels in 1-spot Overnight Urine Specimens Predict the Total Previous 24-hour Melamine Excretion Level in School children. Clin. Chim. Acta 2013, 420, 128-133.
• Cho, Y. T.; Kuo, C. H.; Wang, S. S. W.; Chen, Y. S.; Weng, B. C.; Lee, Y. C.; Cheng, C. N.; Shiea, J.; Wu, D. C., Differentiation of Virulence of Helicobacter Pylori by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry and Multivariate Analyses. Clin. Chim. Acta 2013, 424, 123-130.
• Ou, C. H.; Kuo, F. C.; Hsu, W. H.; Lu, C. Y.; Yu, F. J.; Kuo, C. H.; Wang, J. Y.; Wu, M. T.; Shiea, J.; Wu, D. C.; Hu, H. M., Comparison of the Performance of Guaiac-based and Two Immunochemical Fecal Occult Blood Tests for Identifying Advanced Colorectal Neoplasia in Taiwan. J. Dig. Dis. 2013, 14(9), 474-83.
• Huang, M. Z.; Zhou, C. C.; Liu, D. L.; Jhang, S. S.; Cheng, S. C.; Shiea, J., Rapid Characterization of Chemical Compounds in Liquid and Solid States Using Thermal Desorption Electrospray Ionization Mass Spectrometry. Anal. Chem. 2013, 85(19), 8956-8963.
• Huang, T. L.; Cho, Y. T.; Su, H.; Shiea. J., Principle Component Analysis Combined with Matrix-assisted Laser Desorption Ionization Mass Spectrometry for Rapid Diagnosing the Sera of Patients with Major Depression.Clin. Chim. Acta 2013, 424, 175-181.
• Kao, Y. Y.; Cheng, C. N.; Cheng, S. C.; Ho, H. O.; Shiea, J., Distinguishing Authentic and Counterfeit Banknotes by Surface Chemical Composition Determined Using Electrospray Laser Desorption Ionization Mass Spectrometry. J. Mass Spectrom. 2013, 48(11), 1129-1135.
• Wu, C. F.; Chen, B. H.; Shiea, J. T.; Chen, E. K.; Liu, C. K.; Chao, M. C.; Ho, C. K.; Wu, J. R.; Wu, M. T., Temporal Changes of Urinary Oxidative Metabolites of Di(2-ethylhexyl)phthalate After the 2011 Phthalate Incident in Taiwanese Children: Findings of a Six Month Follow-Up. Environ. Sci. Technol. 2013, 47(23), 13754-13762.

2012

• Chuang, C. H.; Chuang, K. H.; Wang, H. E.; Roffler, S. R.; Shiea, J. T.; Tzou, S. C.; Cheng, T. C.; Kao, C. H.; Wu, S. Y.; Tseng, W. L.; Cheng, C. M.; Hou, M. F.; Wang, J. M.; Cheng, T. L., In Vivo Positron Emission Tomography Imaging of Protease Activity by Generation of a Hydrophobic Product from a Noninhibitory Protease Substrate. Clin. Cancer Res. 2012, 18(1), 238-47.
• Cho, Y. T.; Chen, Y. S.; Hu, J. L.; Shiea, J.; Yeh, S. M.; Chen, H. C.; Lee, Y. C.; Wu, D. C., The Study of Interferences for Diagnosing Albuminuria by Matrix-assisted Laser Desorption Ionization/Time-of-flight Mass Spectrometry. Clin. Chim. Acta 2012, 413(9-10), 875-882.
• Y. T. Cho , Y. Y. Chiang, J. Shiea, M. F. Hou, Combining MALDI-TOF and Molecular Imaging with Principal Component Analysis for Biomarker Discovery and Clinical Diagnosis of Cancer. Genomic Medicine, Biomarkers, and Health Sciences. 2012, 4, 3-6.
• Kuo, H. K.; Chen, Y. H.; Wu, P. C.; Wu, Y. C.; Huang, F.; Kuo, C. W.; Lo, L. H.; Shiea, J., Attenuated Glial Reaction in Experimental Proliferative Vitreoretinopathy Treated with Liposomal Doxorubicin. Invest. Ophthalmol. Visual Sci. 2012, 53(6), 3167-74.
• Cheng, S. C.; Huang, M. Z.; Wu, L. C.; Chou, C. C.; Cheng, C. N.; Jhang, S. S.; Shiea, J., Building Blocks for the Development of an Interface for High-Throughput Thin Layer Chromatography/Ambient Mass Spectrometric Analysis: A Green Methodology. Anal. Chem. 2012, 84(14), 5864-5868.
• Huang, M. Z.; Cheng, S. C.; Jhang, S. S.; Chou, C. C.; Cheng, C. N.; Shiea, J.; Popov, I. A.; Nikolaev, E. N., Ambient Molecular Imaging of Dry Fungus Surface by Electrospray Laser Desorption Ionization Mass Spectrometry. Int. J. Mass Spectrom. 2012, 325, 172-182.
• Chin, K. H.; Lin, C. R.; Huang, H. W.; Shiea, J.; Liu, L. L., Toxic Effects of Two Brominated Flame Retardants BDE-47 and BDE-183 on the Survival and Protein Expression of the Tubificid Monopylephorus Limosus. Ecotoxicol. Environ. Saf. 2012, 84, 46-53.
• Liu, C. C.; Wu, C. F.; Shiea, J.; Cho, Y. T.; Hsieh, T. J.; Chou, Y. H.; Chen, B. H.; Huang, S. P.; Wu, W. J.; Shen, J. T.; Chang, M. Y.; Huang, C. H.; Chang, A. W.; Wu, M. T., Detection of Melamine in a Human Renal Uric Acid Stone by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry (MALDI-TOF MS). Clin. Chim. Acta 2012, 413(19-20), 1689-1695.

2011

• Chien, C. Y.; Wu, C. F.; Liu, C. C.; Chen, B. H.; Huang, S. P.; Chou, Y. H.; Chang, A. W.; Lee, H. H.; Pan, C. H.; Wu, W. J.; Shen, J. T.; Chang, M. Y.; Huang, C. H.; Shiea, J.; Hsieh, T. J.; Wu, M. T., High Melamine Migration in Daily-use Melamine-made Tableware. J. Hazard. Mater. 2011, 188(1-3), 350-356.
• Cheng, S. C.; Huang, M. Z.; Shiea, J., Thin Layer Chromatography/Mass Spectrometry. J. Chromatogr. A. 2011, 1218(19), 2700-2711.
• Kuo, S. M.; Yang, C. C.; Shiea, J.; Lin, C. H., A Post-bonding-free Fabrication of Integrated Microfluidic Devices for Mass Spectrometry Applications. Sensor Actuat. B-Chem. 2011, 156(1), 156-161.
• Huang, M. Z.; Cheng, S. C.; Cho, Y. T.; Shiea, J., Ambient Ionization Mass Spectrometry: A Tutorial. Anal. Chim. Acta 2011, 702(1), 1-15.
• Lin, Y. C.; Chiu, K. H.; Shiea, J.; Huang, H. W.; Mok, H. K., Seasonal Changes in Atrophy-associated Proteins of the Sonic Muscle in the Big-snout Croaker, Johnius Macrorhynus (Pisces, Sciaenidae), Identified by Using a Proteomic Approach. Fish Physiol. Biochem. 2011, 37(4), 977-991.

2010

• Cheng, S. C.; Lin, Y. S.; Huang, M. Z.; Shiea, J., Applications of Electrospray Laser Desorption Ionization Mass Spectrometry for Document Examination. Rapid Commun. Mass Spectrom. 2010, 24(2), 203-208.
• Hung, W. C.; Tseng, W. L.; Shiea, J.; Chang, H. C., Skp2 Overexpression Increases the Expression of MMP-2 and MMP-9 and Invasion of Lung Cancer Cells. Cancer Lett. 2010, 288(2), 156-161.
• Huang, M. Z.; Jhang, S. S.; Cheng, C. N.; Cheng, S. C.; Shiea, J., Effects of Matrix, Electrospray Solution, and Laser Light on the Desorption and Ionization Mechanisms in Electrospray-assisted Laser Desorption Ionization Mass Spectrometry. Analyst. 2010, 135(4), 759-766.
• Huang, M. Z.; Yuan, C. H.; Cheng, S. C.; Cho, Y. T.; Shiea, J., Ambient Ionization Mass Spectrometry. Annu. Rev. Anal. Chem. 2010, 3, 43-65.
• Chuang, K. H.; Tzou, S. C.; Cheng, T. C.; Kao, C. H.; Tseng, W. L.; Shiea, J.; Liao, K. W.; Wang, Y. M.; Chang, Y. C.; Huang, B. J.; Wu, C. J.; Chu, P. Y.; Roffler, S. R.; Cheng, T. L., Measurement of Poly(ethylene glycol) by Cell-based Anti-poly(ethylene glycol) ELISA. Anal. Chem. 2010, 82(6), 2355-2362.
• Chuang, K. H.; Wang, H. E.; Chen, F. M.; Tzou, S. C.; Cheng, C. M.; Chang, Y. C.; Tseng, W. L.; Shiea, J.; Lin, S. R.; Wang, J. Y.; Chen, B. M.; Roffler, S. R.; Cheng, T. L., Endocytosis of PEGylated Agents Enhances Cancer Imaging and Anticancer Efficacy. Mol. Cancer Ther. 2010, 9(6), 1903-12.
• Wang, H. Y.; Lo, L. H.; Tyan, Y. C.; Chen, H. C.; Yang, M. H.; Chen, T. Y.; Wang, H. Y. J.; Shiea, J., The Study of the Distribution of Melamine in Rat Renal Tissues by Imaging Mass Spectrometry. Anal. Methods-Uk. 2010, 2(12), 1974-1981.
• Lo, L. H.; Wu, P. C.; Wu, Y. C.; Shiea, J., Characterization of Human Neutrophil Peptides (alpha-Defensins) in the Tears of Dry Eye Patients. Anal. Methods-Uk. 2010, 2(12), 1934-1940.

2009

• Cheng, C. M.; Chu, P. Y.; Chuang, K. H.; Roffler, S. R.; Kao, C. H.; Tseng, W. L.; Shiea, J.; Chang, W. D.; Su, Y. C.; Chen, B. M.; Wang, Y. M.; Cheng, T. L., Hapten-derivatized Nanoparticle Targeting and Imaging of Gene Expression by Multimodality Imaging Systems. Cancer Gene Ther. 2009, 16(1), 83-90.
• Lo, L. H.; Huang, T. L.; Shiea, J., Acid Hydrolysis Followed by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry for the Rapid Diagnosis of Serum Protein Biomarkers in Patients with Major Depression. Rapid Commun. Mass Spectrom. 2009, 23(5), 589-598.
• Chen, Y. H.; Wu, P. C.; Shiea, J.; Lo, L. H.; Wu, Y. C.; Kuo, H. K., Evaluation of the Sterility, Stability, and Efficacy of Bevacizumab Stored in Multiple-dose Vials for 6 Months. J. Ocul. Pharmacol. Th. 2009, 25(1), 65-69.
• Cheng, S. C.; Cheng, T. L.; Chang, H. C.; Shiea, J., Using Laser-Induced Acoustic Desorption/Electrospray Ionization Mass Spectrometry To Characterize Small Organic and Large Biological Compounds in the Solid State and in Solution under Ambient Conditions. Anal. Chem. 2009, 81(3), 868-874.
• Huang, P. Y.; Lo, L. H.; Chen, Y. C.; Lin, R. T.; Shiea, J.; Liu, C. K., Serum Free Hemoglobin as a Novel Potential Biomarker for Acute Ischemic Stroke. J. Neurol. 2009, 256(4), 625-631.
• Tzou, S. C.; Roffler, S.; Chuang, K. H.; Yeh, H. P.; Kao, C. H.; Su, Y. C.; Cheng, C. M.; Tseng, W. L.; Shiea, J.; Harm, I. H.; Cheng, K. W.; Chen, B. M.; Hwang, J. J.; Cheng, T. L.; Wang, H. E., Micro-PET Imaging of beta-Glucuronidase Activity by the Hydrophobic Conversion of a Glucuronide Probe. Radiology 2009, 252(3), 754-62.
• Tyan, Y. C.; Yang, M. H.; Jong, S. B.; Wang, C. K.; Shiea, J., Melamine Contamination. Anal. Bioanal. Chem. 2009, 395(3), 729-735.
• Yang, M. H.; Lo, L. H.; Chen, Y. H.; Shiea, J.; Wu, P. C.; Tyan, Y. C.; Jong, Y. J., Study of Human Neutrophil Peptides in Saliva by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry. Rapid Commun. Mass Spectrom. 2009, 23(19), 3220-6.
• Cheng, S. C.; Huang, M. Z.; Shiea, J., Thin-Layer Chromatography/Laser-induced Acoustic Desorption/Electrospray Ionization Mass Spectrometry. Anal. Chem. 2009, 81(22), 9274-9281.

2008

• Shiea, J.; Yuan, C. H.; Huang, M. Z.; Cheng, S. C.; Ma, Y. L.; Tseng, W. L.; Chang, H. C.; Hung, W. C., Detection of Native Protein Ions in Aqueous Solution under Ambient Conditions by Electrospray Laser Desorption/Ionization Mass Spectrometry. Anal. Chem. 2008, 80(13), 4845-4852.
• Cheng, C. M.; Lu, Y. L.; Chuang, K. H.; Hung, W. C.; Shiea, J.; Su, Y. C.; Kao, C. H.; Chen, B. M.; Roffler, S.; Cheng, T. L., Tumor-targeting Prodrug-activating Bacteria for Cancer Therapy. Cancer Gene Ther. 2008, 15(6), 393-401.
• Peng, I. X.; Loo, R. R. O.; Shiea, J.; Loo, J. A., Reactive-electrospray-assisted Laser Desorption/Ionization for Characterization of Peptides and Proteins. Anal. Chem. 2008, 80(18), 6995-7003.
• Chuang, P. H.; Hsieh, P. W.; Yang, Y. L.; Hua, K. F.; Chang, F. R.; Shiea, J.; Wu, S. H.; Wu, Y. C., Cyclopeptides with Anti-inflammatory Activity from Seeds of Annona Montana. J. Nat. Prod. 2008, 71(8), 1365-1370.
• Cheng, C. Y.; Yuan, C. H.; Cheng, S. C.; Huang, M. Z.; Chang, H. C.; Cheng, T. L.; Yeh, C. S.; Shiea, J., Electrospray-assisted Laser Desorption/Ionization Mass Spectrometry for Continuously Monitoring the States of Ongoing Chemical Reactions in Organic or Aqueous Solution under Ambient Conditions. Anal. Chem. 2008, 80(20), 7699-7705.
• Wu, I. C.; Wu, M. T.; Chen, Y. K.; Hsu, M. C.; Chou, S. H.; Lee, C. H.; Shiea, J. T.; Wu, I. L.; Huang, C. T.; Wu, D. C., Apoptotic Effect of Helicobacter Pylori on Oesophageal Squamous-cell Carcinoma Cells in Vitro. Eur. J. Clin. Invest. 2008, 38(10), 760-765.
• Shiea, J.; Cho, Y. T.; Lin, Y. H.; Chang, C. W.; Lo, L. H.; Lee, Y. C.; Ke, H. L.; Wu, W. J.; Wu, D. C., Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry to Rapidly Screen for Albuminuria. Rapid Commun. Mass Spectrom. 2008, 22(23), 3754-3760.

2007

• Pan, C. T.; Shiea, J.; Shen, S. C., Fabrication of an Integrated Piezo-electric Micro-nebulizer for Biochemical Sample Analysis. J. Micromech. Microeng. 2007, 17(3), 659-669.
• Shiea, J.; Sunner, J., The Encyclopedia of Mass Spectrom. (ed. M. Gross). Fused-Droplet Electrospray Ionization and Electrospray Laser Desorption Ionization. Elsevier,2007, 6, 528-532.
• Lee, K. H.; Chen, S. J.; Jeng, J. Y.; Cheng, Y. C.; Shiea, J. T.; Chang, H. T., Fluorescence and Interactions with Thiol Compounds of Nile Red-adsorbed Gold Nanoparticles. J. Colloid. Interf. Sci. 2007, 307(2), 340-348.
• Hsu, H. J.; Oung, J. N.; Kuo, T. L.; Wu, S. H.; Shiea, J., Using Electrospray-assisted Pyrolysis Ionization/Mass Spectrometry for the Rapid Characterization of Trace Polar Components in Crude Oil, Amber, Humic Substances, and Rubber Samples. Rapid Commun. Mass Spectrom. 2007, 21(3), 375-384.
• Peng, I. X.; Shiea, J.; Loo, R. R. O.; Loo, J. A., Electrospray-assisted Laser Desorption/Ionization and Tandem Mass Spectrometry of Peptides and Proteins. Rapid Commun. Mass Spectrom. 2007, 21(16), 2541-2546.
• Jeng, J. Y.; Lin, M. F.; Cheng, F. Y.; Yeh, C. S.; Shiea, J. T., Using High-concentration Trypsin-immobilized Magnetic Nanoparticles for Rapid in Situ Protein Digestion at Elevated Temperature. Rapid Commun. Mass Spectrom. 2007, 21(18), 3060-3068.
• Wu, C. I.; Tsai, C. C.; Lu, C. C.; Wu, P. C.; Wu, D. C.; Lin, S. Y.; Shiea, J., Diagnosis of Occult Blood in Human Feces Using Matrix-assisted Laser Desorption Ionization/Time-of-flight Mass Spectrometry. Clin. Chim. Acta 2007, 384(1-2), 86-92.
• Lin, S. Y.; Shih, S. H.; Wu, D. C.; Lee, Y. C.; Wu, C. I.; Lo, L. H.; Shiea, J., Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry for the Detection of Hemoglobins as the Protein Biomarkers for Fecal Occult Blood. Rapid Commun. Mass Spectrom. 2007, 21(20), 3311-3316.
• Lin, S. Y.; Huang, M. Z.; Chang, H. C.; Shiea, J., Using Electrospray-assisted Laser Desorption/Ionization Mass Spectrometry to Characterize Organic Compounds Separated on Thin-layer Chromatography Plates. Anal. Chem. 2007, 79(22), 8789-8795.

2006

• Huang, M. Z.; Hsu, H. J.; Lee, L. Y.; Jeng, J. Y.; Shiea, J. T., Direct Protein Detection from Biological Media Through Electrospray-assisted Laser Desorption Ionization/Mass Spectrometry. J. Proteome Res. 2006, 5(5), 1107-1116.
• Chiu, Y. K.; Huang, C. C.; Jeng, J.; Shiea, J.; Chen, W. J., Foreign Body Granuloma Caused by Monosodium Glutamate After BCG Vaccination. J. Am. Acad. Dermatol. 2006, 55(2), S1-S5.

2005

• Chen, C. N.; Jones, P. R.; Shiea, J., Detection of Preformed Macrocyclic Nickel Complex Ions Using Two-step Electrospray Ionization Mass Spectrometry. J. Mass Spectrom. 2005, 40(3), 413-415.
• Shieh, I. F.; Lee, C. Y.; Shiea, J., Eliminating the Interferences from TRIS Buffer and SDS in Protein Analysis by Fused-droplet Electrospray Ionization Mass Spectrometry. J. Proteome Res. 2005, 4(2), 606-612.
• H. J. Hsu, T. L. Kuo, S. H. Wu, J. N. Oung, J. Shiea, Characterization of Synthetic Polymers by Electrospray-assisted Pyrolysis Ionization-mass Spectrometry. Anal. Chem. 2005, 77, 7744-7749.
• Jeng, J. Y.; Lin, C. H.; Shiea, J., Electrospray from Nanostructured Tungsten Oxide Surfaces with Ultralow Sample Volume. Anal. Chem. 2005, 77(24), 8170-8173.
• Shiea, J.; Huang, M. Z.; Su, H. J.; Lee, C. Y.; Yuan, C. H.; Beech, I.; Sunner, J., Electrospray-assisted Laser Desorption/Ionization Mass Spectrometry for Direct Ambient Analysis of Solids. Rapid Commun. Mass Spectrom. 2005, 19(24), 3701-3704.
• Hsu, J. L.; Huang, S. Y.; Shiea, J. T.; Huang, W. Y.; Chen, S. H., Beyond Quantitative Proteomics: Signal Enhancement of the a(1) Ion as a Mass Tag for Peptide Sequencing Using Dimethyl Labeling. J. Proteome Res. 2005, 4(1), 101-108.

2003

• Hsu, F. L.; Chen, C. H.; Yuan, C. H.; Shiea, J., Interfaces to Connect Thin-layer Chromatography with Electrospray Ionization Mass Spectrometry. Anal. Chem. 2003, 75(10), 2493-2498.
• Jeng, J. Y.; Shiea, J., Electrospray Ionization from a Droplet Deposited on a Surface-modified Glass Rod. Rapid Commun. Mass Spectrom. 2003, 17(15), 1709-1713.
• Shiea, J. T.; Huang, J. P.; Teng, C. F.; Jeng, J. Y.; Wang, L. Y.; Chiang, L. Y., Use of a Water-soluble Fullerene Derivative as Precipitating Reagent and Matrix-assisted Laser Desorption/Ionization Matrix to Selectively Detect Charged Species in Aqueous Solutions. Anal. Chem. 2003, 75(14), 3587-3595.

2002

• Lee, C. C.; Chang, D. Y.; Jeng, J.; Shiea, J., Generating Multiply Charged Protein Ions via Two-step Electrospray Ionization Mass Spectrometry. J. Mass Spectrom. 2002, 37(1), 115-7.
• Chang, D. Y.; Lee, C. C.; Shiea, J., Detecting Large Biomolecules from High-salt Solutions by Fused-droplet Electrospray Ionization Mass Spectrometry. Anal. Chem. 2002, 74(11), 2465-2469.
• Hsiu, S. I.; Huang, J. F.; Sun, I. W.; Yuan, C. H.; Shiea, J., Lewis Acidity Dependency of the Electrochemical Window of Zinc Chloride-1-ethyl-3-methylimidazolium Chloride Ionic Liquids. Electrochim Acta 2002, 47(27), 4367-4372.

2001

• Yuan, C. H.; Shiea, J., Sequential Electrospray Analysis Using Sharp-tip Channels Fabricated on a Plastic Chip. Anal. Chem. 2001, 73(6), 1080-1083.
• Leu, C. M.; Shu, C. F.; Teng, C. F.; Shiea, J., Dendritic Poly(ether-imide)s: Synthesis, Characterization, and Modification. Polymer 2001, 42(6), 2339-2348.
• Wang, L. Y.; Chu, C. C.; Shiea, J.; Chiang, L. Y., Synthesis and Characterization of Star-brabched Oilgoanilines. Synthetic Metals. 2001, 119, 97-98.
• Chen, H. J. C.; Chen, Y. M.; Wang, T. F.; Wang, K. S.; Shiea, J., 8-nitroxanthine, an Adduct Derived from 2 '-deoxyguanosine or DNA Reaction with Nitryl Chloride. Chem. Res. Toxicol. 2001, 14(5), 536-546.
• Shiea, J.; Chang, D. Y.; Lin, C. H.; Jiang, S. J., Generating Multiply Charged Protein Ions by Ultrasonic Nebulization/Multiple Channel-electrospray Ionization Mass Spectrometry. Anal. Chem. 2001, 73(20), 4983-4987.

2000

• Chen, Y. C.; Shiea, J.; Sunner, J., Rapid Determination of Trace Nitrophenolic Organics in Water by Combining Solid-phase Extraction with Surface-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry. Rapid Commun. Mass Spectrom. 2000, 14(2), 86-90.
• Hong, C. M.; Tsai, F. C.; Shiea, J., A Multiple Channel Electrospray Source Used to Detect Highly Reactive Ketenes from a Flow Pyrolyzer. Anal. Chem. 2000, 72(6), 1175-1178.
• Leu, C. M.; Chang, Y. T.; Shu, C. F.; Teng, C. F.; Shiea, J., Synthesis and Characterization of Dendritic Poly(ether imide)s. Macromolecules 2000, 33(8), 2855-2861.
• Kuo, C. P.; Yuan, C. H.; Shiea, J., Generation of Electrospray from a Solution Predeposited on Optical Fibers Coiled with a Platinum Wire. J. Am. Soc. Mass Spectrom. 2000, 11(5), 464-467.

1999

• Hong, C. M.; Lee, C. T.; Lee, Y. M.; Kuo, C. P.; Yuan, C. H.; Shiea, J., Generating Electrospray from Solutions Predeposited on a Copper Wire. Rapid Commun. Mass Spectrom. 1999, 13(1), 21-25.
• Huang, M. W.; Chei, H. L.; Huang, J. P.; Shiea, J., Application of Organic Solvents as Matrixes to Detect Air-sensitive and Less Polar Compounds Using Low-temperature Secondary Ion Mass Spectrometry. Anal. Chem. 1999, 71(14), 2901-2907.
• Huang, J. P.; Wang, L. Y.; Chiang, L. Y.; Shiea, J., Polyfunctional Fullerene Derivatives as UV-MALDI Matrices to Detect Peptides and Proteins. Fullerene Sci. Techn. 1999, 7(4), 541-550.
• Huang, J. P.; Yuan, C. H.; Shiea, J.; Chen, Y. C., Rapid Screening for Diuretic Doping Agents in Urine by C(60)-assisted Laser-desorption-ionization-time-of-flight Mass Spectrometry. J. Anal. Toxicol. 1999, 23(5), 337-342.
• Kuo, C. P.; Shiea, J., Applications of Direct Electrospray Probe/Mass Spectrometry to Detect Proteins in Liquid and Solid Phase and to Couple to Solid Phase Mircoextraction to Detect Trace Surfactants in Water. Anal. Chem. 1999, 71, 4413-4417.

1998

• Chen, B. H.; Huang, J. P.; Wang, L. Y.; Shiea, J.; Chen, T. L.; Chiang, L. Y., Synthesis of Octadecahydroxylated C-70. Synthetic Commun. 1998, 28(19), 3515-3525.
• Chen, B. H.; Huang, J. P.; Wang, L. Y.; Shiea, J.; Chen, T. L.; Chiang, L. Y., Facile Sulfation of C-60 Using P2O5 as an Oxidation Promoter. J. Chem. Soc. Perkin Trans. 1 1998, (7), 1171-1173.
• Chi, Y.; Bhonsle, J. B.; Canteenwala, T.; Huang, J. P.; Shiea, J.; Chen, B. J.; Chiang, L. Y., Novel Water-soluble Hexa(sulfobutyl)fullerenes as Potent Free Radical Scavengers. Chem. Lett. 1998, (5), 465-466.
• Lee, C. Y.; Shiea, J., Gas Chromatography Connected to Multiple Channel Electrospray Ionization Mass Spectrometry for the Detection of Volatile Organic Compounds. Anal. Chem. 1998, 70(13), 2757-2761.
• Chen, Y. C.; Shiea, J.; Sunner, J., Thin-layer Chromatography Mass Spectrometry Using Activated Carbon, Surface-assisted Laser Desorption/Ionization. J. Chromatogr. A. 1998, 826(1), 77-86.
• Wang, C. H.; Huang, M. W.; Lee, C.Y.; Huang, J. B.; Shiea, J, Dection of Thermally Unstable Intermediate in the Wittig Reaction Using Low Temperature Liquid Secondary Ion and Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. 1998, 9, 1168-1174.
• Wang, W. S.; Tseng, P. W.; Chou, C. H.; Shiea, J., Detection of Reactive 1,2,3-hexatriene-5-one Monomer by Low-temperature Atmospheric Pressure Ionization Mass Spectrometry. Rapid Commun. Mass Spectrom. 1998, 12(14), 931-934.

1997

• Shia, J. T.; Wang, C. H., Applications of Multiple Channel Electrospray Ionization Sources for Biological Sample Analysis. J. Mass Spectrom. 1997, 32(2), 247-250.

1996

• J. Shiea, W. S. Wang, C. H. Wang, P. S. Chen, C. H. Chou.; Analysis of a Reactive Dimethylenedihydrothiophene in Methylene-chloride by Low-temperature Atmospheric-pressure Ionization Mass-spectrometry. Anal. Chem. 1996, 68, 1062-1066.
• Chen, Y. C.; Chei, H. L.; Shiea, J., Analysis of Gaseous Ammonia, Volatile Primary Amines and Quaternary Ammonium Salts at Subambient Temperature by Liquid Secondary Ion Mass Spectrometry. J. Mass Spectrom. 1996, 31(5), 464-471.

1995

• Chen, Y. C.; Shiea, J., Selective Enhancement of Ion Signal of Charged Surfactant in Fast-atom-bombardment Mass-spectrometry. J. Mass Spectrom. 1995, 30(10), 1435-1440.

專利